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Structural Studies of Escherichia coli formamidopyrimidine DNA N-glycosylase and its main biiological ksubstrate 8-oxoguanine


EMSL Project ID
1787

Abstract

Elucidate the NMR solution structures as well as the structures of DNA molecules containing 8-oxoguanine the main lesion recognized by this protein in sequence context that either facilitate or hinder this recognition.

Project Details

Project type
Capability Research
Start Date
1999-04-01
End Date
1999-10-01
Status
Closed

Team

Principal Investigator

Susan Wallace
Institution
University of Vermont

Related Publications

G.W. Buchko, K. McAteer, S.S. Wallace, and M.A. Kennedy. (2005) Solution-state NMR investigation of DNA binding interactions in Escherichia coli formamidopyrimidine-DNA glycosylase (Fpg): A dynamic description of the DNA/protein interface. DNA Repair, 4:327-339.