Structural Studies of Escherichia coli formamidopyrimidine DNA N-glycosylase and its main biiological ksubstrate 8-oxoguanine
EMSL Project ID
1787
Abstract
Elucidate the NMR solution structures as well as the structures of DNA molecules containing 8-oxoguanine the main lesion recognized by this protein in sequence context that either facilitate or hinder this recognition.
Project Details
Project type
Capability Research
Start Date
1999-04-01
End Date
1999-10-01
Status
Closed
Released Data Link
Team
Principal Investigator
Related Publications
G.W. Buchko, K. McAteer, S.S. Wallace, and M.A. Kennedy. (2005) Solution-state NMR investigation of DNA binding interactions in Escherichia coli formamidopyrimidine-DNA glycosylase (Fpg): A dynamic description of the DNA/protein interface. DNA Repair, 4:327-339.