Biomarker discovery in pathogens by proteomics
EMSL Project ID
18428
Abstract
The ability to respond adequately to a biological threat requires not only rapid and accurate detection, but also a detailed understanding of the threat agent to determine the appropriate response actions. The objective of this work is to monitor real-time expression of virulence factors to gain a better mechanistic understanding of plague. Specifically, we will utilize mass spectrometry-based proteomics approaches to identify differential protein expression in Yersinia pestis pestis and Fransicella tularensis as a function of virulence by mimicking temperature and calcium concentrations of host and flea vector thus providing protein detection biomarkers for plague and define novel virulence factors.
Project Details
Start Date
2006-03-16
End Date
2008-04-17
Status
Closed
Released Data Link
Team
Principal Investigator