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Comparative Display of D. radiodurans after exposure to Ionizing Radiation


EMSL Project ID
2367

Abstract

Deinococcus radiodurans is one of the most radiation resistant organisms known to man, yet after a comprehensive analysis of the sequenced genome, the mechanisms underlying this radiation resistance remain elusive. The key to understanding the mechanisms of this organism lie in the understanding of the protein expression patterns after exposure to ionizing radiation. Cells will be exposed to acute doses of ionizing radiation and sent to EMSL. From there, the quantitative protein expression patterns will be determined by established comparitive display methodologies, using the state of the art mass spectrometry instrumentation housed in the EMSL.

Project Details

Project type
Exploratory Research
Start Date
2001-09-01
End Date
2004-02-16
Status
Closed

Team

Principal Investigator

Michael Daly
Institution
Uniformed Services University of the Health Sciences