Biotemplated nanoparticles for imaging and drug delivery
EMSL Project ID
30493
Abstract
The objective of this project is to develop new approaches to prepare encoded bimetallic nanoparticles in protein cages for biosensing and imaging. The unique optical and electrochemical signals of encoded bimetallic alloys, which depend on composition ratios of metal alloys, can be used for multiplexed detection and as fingerprints of a specific protein biomarker and reduce false positive alarm. The specific aims of the project are: 1) understand the effect of solution chemistry and protein cage chemistry on the diffusion and reduction of different metal ions, and 2) facilitate a new multiplex sensing platform based on electrochemical and optical techniques.
Project Details
Project type
Large-Scale EMSL Research
Start Date
2008-09-01
End Date
2009-09-30
Status
Closed
Released Data Link
Team
Principal Investigator
Team Members
Related Publications
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Wang Y, Z Li, J Wang, J Li, and Y Lin. 2011. "Graphene and Graphen Oxide: Biofunctionalization and Applications in Biotechnology." Trends in Biotechnology 29(5):205-212. doi:10.1016/j.tibtech.2011.01.008
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Zhang S, Y Shao, G Yin, and Y Lin. 2010. "Carbon nanotubes decorated with Pt nanoparticles via electrostatic self-assembly: a highly active oxygen reduction electrocatalyst ." Journal of Materials Chemistry 20(15):2826-2830. doi:10.1039/b919494k
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Protein-Based Nanomedicine Platforms for Drug Delivery
Ma Ham A, Z Tang, H Wu, J Wang, and Y Lin. 2009. "Protein-Based Nanomedicine Platforms for Drug Delivery." Small 5(15):1706-1721. doi:10.1002/smll.200801602