Ultrastructural Properties of SIS
EMSL Project ID
4695
Abstract
Porcine small intestinal submucosa (SIS) is a naturally derived, collagen-based extracellular matrix that has been used extensively in humans as a biomaterial without complication. Scanning electron microscopy (SEM) has previously been used to characterize the structural details of SIS. The sample preparation required for traditional SEM is likely to have introduced ultrastructural artifacts. ESEM requires no preparation of the hydrated sample prior to imaging. To our knowledge, ESEM has never been performed on SIS. The proposed study will address the ultrastructural properties of SIS in its hydrated, dehydrated, and rehydrated states following several sterilization, crosslinking, or digestion treatments.
Project Details
Project type
Exploratory Research
Start Date
2003-09-15
End Date
2004-09-16
Status
Closed
Released Data Link
Team
Principal Investigator