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Ultrastructural Properties of SIS


EMSL Project ID
4695

Abstract

Porcine small intestinal submucosa (SIS) is a naturally derived, collagen-based extracellular matrix that has been used extensively in humans as a biomaterial without complication. Scanning electron microscopy (SEM) has previously been used to characterize the structural details of SIS. The sample preparation required for traditional SEM is likely to have introduced ultrastructural artifacts. ESEM requires no preparation of the hydrated sample prior to imaging. To our knowledge, ESEM has never been performed on SIS. The proposed study will address the ultrastructural properties of SIS in its hydrated, dehydrated, and rehydrated states following several sterilization, crosslinking, or digestion treatments.

Project Details

Project type
Exploratory Research
Start Date
2003-09-15
End Date
2004-09-16
Status
Closed

Team

Principal Investigator

Abram Janis
Institution
Cook Biotech Incorporated