Delivering Poorly Soluble Active Pharmaceutical Ingredients (API's) by Stabilization of the Amorphous Meta-stable State via Polymers and Nano-Porous Materials.
EMSL Project ID
47677
Abstract
We propose to develop a combination of tools here at EMSL to characterize the surface and in-depth chemical composition of micron sized drug delivery particles prepared by two different methods: 1) spray drying and, 2) API mixing with mesoporous substrates. In both cases, the particles will be prepared under various processing conditions and characterized using several high spatial resolution chemical imaging methods, including Secondary Ion Mass Spectrometry (SIMS), X-Ray Photoelecron Spectroscopy (XPS) Secondary Electron Microscopy (SEM) and Energy Dispersive X-ray Spectrometry (EDAX). Surface chemical compositions will be determined using Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) in conjunction with XPS, and subsequently compared to bulk characteristics of cross sectioned particles. Sputter depth profiling using a newly acquired Gas Cluster Ion Beam Source for more detailed profiles of the surface compositions. Optimum distributions will be determined based on the resulting release characteristics.
Project Details
Start Date
2012-11-14
End Date
2013-11-17
Status
Closed
Released Data Link
Team
Principal Investigator
Team Members