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Impact of Cholesterol and Some of its Oxidized Derivatives on DPPC in Langmuir Monolayers


EMSL Project ID
48190

Abstract

The proposed research aims to understand how oxysterols alter the conformation and orientation of lipids in Langmuir monolayers, and how the concentration and chemical modifications of Chol modulate the monolayer/bilayer fluidity at the air/aqueous interface. Addressing these objectives has application more broadly to biomembrane science, mineral- and water-based biofilms, and air/lipid-Chol/water interfacial properties. The PNNL EMSL high resolution vibrational sum frequency generation (HR-VSFG) spectroscopic facility headed by Dr. H-f. Wang is necessary to deconvolve the complex lineshapes in the VSFG spectra for cholesterol - lipid systems.

Project Details

Project type
Exploratory Research
Start Date
2013-12-04
End Date
2014-09-30
Status
Closed

Team

Principal Investigator

Heather Allen
Institution
The Ohio State University

Related Publications

Telesford DM L 2014. "Interfacial Behavior of Cholesterol, 7-Ketocholesteral and 5?,6?-Epoxycholesterol in Phosphatidylcholine Monolayers"