Molecular mechanisms underlying nanomaterial toxicity or biocompatibility
EMSL Project ID
48262
Abstract
Accumulating observations demonstrate the potential of engineered nanoparticles (NPs) to induce adverse environmental and health effects, but the properties that make a particle toxic or biocompatible are still unclear. Distinct physical and chemical properties of the NP engage and activate distinct proteins and cellular pathways that, in turn, govern the fate of the NP and its impact on the cell, and ultimately the impact on organisms in the environment and human health. The relationships between particle properties and these key cellular processes and response are far from being understood. Using EMSL resources for molecular level interrogation of living cells, we will provide detailed characterization of the cellular response elicited by distinct properties of NPs to support accurate relationships between NP properties and cellular mechanisms.
Project Details
Start Date
2014-02-13
End Date
2014-09-30
Status
Closed
Released Data Link
Team
Principal Investigator