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Cryo-EM studies of novel antibiotics bound to the ribosome of the multi-drug resistant organism Acinetobacter Baumannii


EMSL Project ID
50993

Abstract

The global rise in Multiple Drug Resistant (MDR) bacteria promises to make curing common infections impossible, claiming a spot on the Top Ten Threats to Global Health list published by the World Health Organization (WHO, 2019). Indeed, while there has certainly been significant effort in recent years to better understand the various biological factors that confer antibiotic resistance, many questions remain in the race to uncover safe and effective therapies. To help bridge this gap, we propose to utilize structural and biological techniques to characterize the interactions between a number of unique and effective antibiotics and the bacterial ribosome, utilizing the MDR microorganism Acinetobacter baumannii. In doing so, we aim to provide important structural data that will be utilized to develop novel and effective antibiotics against multi-drug resistant bacteria and aid in the fight against the incredible rise in antibiotic resistant bacteria.

Project Details

Start Date
2019-08-01
End Date
2020-02-10
Status
Closed

Team

Principal Investigator

Edward Yu
Institution
Case Western Reserve University

Co-Investigator(s)

Christopher Morgan
Institution
Case Western Reserve University

Team Members

Theo Humphreys
Institution
Oregon Health & Science University