Cryo-EM studies of novel antibiotics bound to the ribosome of the multi-drug resistant organism Acinetobacter Baumannii
EMSL Project ID
50993
Abstract
The global rise in Multiple Drug Resistant (MDR) bacteria promises to make curing common infections impossible, claiming a spot on the Top Ten Threats to Global Health list published by the World Health Organization (WHO, 2019). Indeed, while there has certainly been significant effort in recent years to better understand the various biological factors that confer antibiotic resistance, many questions remain in the race to uncover safe and effective therapies. To help bridge this gap, we propose to utilize structural and biological techniques to characterize the interactions between a number of unique and effective antibiotics and the bacterial ribosome, utilizing the MDR microorganism Acinetobacter baumannii. In doing so, we aim to provide important structural data that will be utilized to develop novel and effective antibiotics against multi-drug resistant bacteria and aid in the fight against the incredible rise in antibiotic resistant bacteria.
Project Details
Start Date
2019-08-01
End Date
2020-02-10
Status
Closed
Released Data Link
Team
Principal Investigator
Co-Investigator(s)
Team Members