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Projects

As a scientific user facility, the Environmental Molecular Sciences Laboratory (EMSL) provides expertise, instrumentation, and resources to 250 projects each year. 

EMSL projects displayed on the EMSL web site project page reflect project abstracts and information migrated to this page before April 30, 2024. To review current and past EMSL user projects, visit EMSL Science Central.™ 

 

Efficient Storage of Hydrogen and Methane

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Thomas Autrey
This proposal will determine the mechanistic and thermodynamic understanding required to address bottlenecks in materials capable of storing hydrogen or methane. We propose a series of experiments…

Micro-dimension Calibration

Lead Institution
XL Science & Technology
Principal Investigator
Y Peng
Project type
Exploratory Research
Precision microfabraicated parts can not be calibrated even with best optical microscope. SEM (FESEM) can provide the depth of field for the ultimate micro-de=imension calibration.

Structure and conformational dynamics of biologically important RNAs

Lead Institution
University of Colorado Anschutz Medical Campus
Principal Investigator
Jeffrey Kieft
RNA’s remarkable functional diversity is conferred by its ability to adopt a seemingly endless variety of structures and undergo programmed conformational dynamics. The emergence of cryo-EM as a…

Structural studies of the targeting factor Get3

Lead Institution
California Institute of Technology
Principal Investigator
William Clemons
Tail-anchored (TA) proteins, accounting for approximately 2% of the genome, are a class of proteins with various functions but all with a single transmembrane domain near their C-terminus. Due to the…

Structural Investigations of Human TRPM4

Lead Institution
Van Andel Research Institute
Principal Investigator
Wei Lu
The aim of this research is to complete the gating cycle of human TRPM4 by solving the structures at multiple functional states at high-resolution. The recently published TRPM4 structures by our lab…

Structural determination of CALHM channels

Lead Institution
Van Andel Research Institute
Principal Investigator
Wei Lu
The calcium homeostasis modulators (CALHMs) are one of the key ATP release channel families, consisting of three members, CALHM1, 2 and 3. They are voltage-dependent, extracellular,…

Multi-marker Urine Test for Detection of Aggressive Prostate Cancer

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Weijun Qian
In prostate cancer disease management over-diagnosis and over-treatment have increasingly become major public concerns. Prostate cancer is primarily detected by serum PSA screening followed by a…

Multiplex Mass Spectrometric Protein Assays for Obesity

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Weijun Qian
The prevalence of overweight and obesity has increased dramatically in recent decades in both children and adults, reaching an epidemic proportion. In order to gain new insights into the…

Structural basis for translocon modulation

Lead Institution
University of Helsinki
Principal Investigator
Ville Paavilainen
Nearly 95% of human secretory and integral membrane proteins are cotranslationally targeted to the Sec61 translocon, which facilitates transport of these proteins into the ER lumen or lipid bilayer…

In situ X-Ray Computed Tomography for study of glass melter operation

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Steven Luksic
X-ray computed tomography (CT) analysis will support waste-glass research by analyzing room-temperature samples and adapting a furnace for use in the CT instrument. Developing a glass-melting furnace…