Projects

Automated Image Analysis of Low Frequency Radiation Induced Genomic Instability in Human Colon Carcinoma Cells

Lead Institution

NASA Ames Research Center

Principal Investigator

Marianne Sowa

Project type

Large-Scale EMSL Research

This proposal is a continuation of research under EMSL User Proposal #21990. Ionizing radiation induced bystander effects are those effects occurring in cells that were not traversed by radiation…

Characterization of solid oxide fuel cell electrodes after exposure

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Olga Marina

Project type

Large-Scale EMSL Research

The purpose of this project is to gain understanding how the fuel electrode chemistry and microstructure is affected by exposure to coal gas contaminants. This is of importance to operating solid…

Hybrid Numerical Methods for Multiscale Modeling of Subsurface Biogeochemical Processes

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Bruce Palmer

Project type

Large-Scale EMSL Research

The project is focused on developing a component-based framework and associated parallel software components for doing large scale simulations of subsurface reactive transport by combining different…

NMR Study of Ion Transport in Nanostructured Materials

Lead Institution

Yale University

Principal Investigator

Jun Liu

Project type

Large-Scale EMSL Research

The transport of charged species (protons and cations such as lithium) in nanomaterials is the most critical phenomenon in energy conversion and storage devices such as proton conducting membranes in…

Proteomics of Populus: Understanding Protein Expression Involved in Carbon Allocation

Lead Institution

Washington State University

Principal Investigator

Jon Johnson

Project type

Large-Scale EMSL Research

With the availability of the sequenced poplar genome, high throughput proteomic evaluations can reveal molecular understanding of how to make trees grow faster and manipulate allocation of carbon…

Product analysis of reactions of a model system for organics on atmospheric particles: Ozonolysis of Self-Assembled Monolayers on Silicon Surfaces

Lead Institution

University of California, Irvine

Principal Investigator

Theresa McIntire

Project type

Large-Scale EMSL Research

Airborne particles have significant effects on climate, visibility, human health and atmospheric reactions. Organics associated with airborne particles are thought to be oxidized to polar,…

Analysis of metabolic responses to signals from the oncogene c-Myc a regulator of cell growth and proliferation.

Lead Institution

Fred Hutchinson Cancer Research Center

Principal Investigator

Fionnuala Morrish

Project type

Large-Scale EMSL Research

The ability of cells to grow, generate energy and respond to environmental stimuli is directly linked to cellular signaling mechanisms. Understand how these signal are regulated is an important…

Determination of the CCR5 and CXCR4 Antagonist and Agonist Binding Site.

Lead Institution

Montana State University

Principal Investigator

Edward Dratz

Project type

Large-Scale EMSL Research

This proposal focuses on determining the locations of the agonist and antagonist binding pockets for the 7-transmembrane spanning G-Protein coupled receptors (GPCR) CCR5 and CXCR4. G-protein coupled…

Proteomic-based mechanistic analysis of components involved in the immunoprotective pathways regulated by low-dose radiation and the medicinal mushroom Trametes versicolor

Lead Institution

Bastyr University

Principal Investigator

Cynthia Wenner

Project type

Large-Scale EMSL Research

The goal of this proposal is to identify molecular mechanisms that underlie radio-adaptive immune responses. We propose to use quantitative mass spectrometry to investigate the effects of…

Doping inorganic wide-bandgap semiconductors for future energy devices

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Weilin Jiang

Project type

Large-Scale EMSL Research

Solid-state lighting (SSL) has a significantly higher efficiency of converting electricity to visible light compared to the incandescent (5%) or fluorescent (20%) lighting due to elimination of…

Coprecipitation of Aluminum Hydroxides and Calcium Carbonates during Denitrification: A Stabilization Strategy for Oxidized Metals and Radionuclides

Lead Institution

Oregon State University

Principal Investigator

Jonathan Istok

Project type

Large-Scale EMSL Research

Research conducted at the Field Research Center (FRC) at Oak Ridge National Laboratory and at the Old Rifle site has demonstrated that it is possible to stimulate indigenous microbial activity and…

Validation of Whole-Core Determination of Soil Hydraulic Properties

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Michael Fayer

Project type

Large-Scale EMSL Research

The EMSL Subsurface Flow and Transport Laboratory developed a fully automated Hydraulic Property Apparatus (HPA) that is a significant advance in measurement technology. The HPA uses the multistep…

Measurement and Optimization of the Redox Properties of Enzymes Using Single-Molecule Imaging, Controlled Electrochemical Potential, and Nanoscale Confinement

Lead Institution

Western University of Health Sciences

Principal Investigator

Thomas Squier

Project type

Large-Scale EMSL Research

We propose a new multi-disciplinary approach to single-molecule spectroscopy to image the redox kinetics of enzymes in spatially confined geometries under controlled electrochemical potential. We…

Thermodynamic and Chemical Properties of La1-xSrxCoxFe1-xO3 from First-Principles Calculations: Implications for Use as SOFC Cathodes

Lead Institution

University of Florida

Principal Investigator

Susan Sinnott

Project type

Large-Scale EMSL Research

The objective of the proposed research is to obtain an atomic-level understanding of heterogeneous electrocatalytic phenomena at the surface of mixed conducting solid oxide fuel cell (SOFC) cathodes…

Ground squirrel proteome: protein modifications through torpor and arousal

Lead Institution

University of Colorado

Principal Investigator

Lois Epperson

Project type

Large-Scale EMSL Research

Liver samples from the hibernator, golden-mantled ground squirrel, when separated by 2D gel electrophoresis, demonstrate a quantifiable and as yet undefined physical modification that manifests…

Comparative Proteomic Analysis of Naturally Occurring Anaerobic Methane Oxidizing Communities

Lead Institution

University of British Columbia

Principal Investigator

Steven Hallam

Project type

Large-Scale EMSL Research

Methane is a potent greenhouse gas whose atmospheric concentration has increased significantly due to anthropogenic activities and fluctuated naturally over glacial and interglacial cycles. While…

Community Proteomic Analysis of a Near-Shore Anoxic Basin: Saanich Inlet

Lead Institution

University of British Columbia

Principal Investigator

Steven Hallam

Project type

Large-Scale EMSL Research

Oxygen minimum zones (OMZs; areas of low dissolved oxygen concentrations) play a major role in biogeochemical cycling within the world's oceans. They are major sinks for nitrogen and sources for…

Mössbauer Spectroscopy and SEM/TEM Study of the
Reductive Dissolution of Fe-Oxyhydroxides in Porous Media

Lead Institution

Lawrence Berkeley National Laboratory

Principal Investigator

Carl Steefel

Project type

Large-Scale EMSL Research

The microbially-mediated reductive dissolution of Fe(III)-oxyhydroxides plays an important role in regulating the redox state of subsurface soils and aquifers, a critical control on the mobility of…

Molecular Interfaces to Single-crystal Anatase Surfaces

Lead Institution

University of Wisconsin, Madison

Principal Investigator

Robert Hamers

Project type

Large-Scale EMSL Research

The anatase form of TiO2 is of great interest as a substrate for a variety of photochemical and photoelectrochemical pathways for solar-to-electrical and solar-to-fuel conversion. A number of…

Development of a Microfluidics Flow and Transport Laboratory

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Mart Oostrom

Project type

Large-Scale EMSL Research

The Environmental Spectroscopy and Biogeochemistry (ESB) Facility, in collaboration with the University of Illinois at Champaign/Urbana, proposes to develop a microfluidics capability to investigate…