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Adelinda Yee

Institution
University of Toronto (Univ. Health Network)

Projects

Protein Interactions and Interfaces

Lead Institution
Rutgers University
Principal Investigator
Gaetano Montelione
Project type
Large-Scale EMSL Research
All proteins interact with other molecules: ligands, metals, membranes, surfaces or other proteins. Such interactions are intrinsic to protein function. We propose to leverage our successful program…

Structural Proteomics: annotating the genome using 3D structure

Lead Institution
University of Toronto (Univ. Health Network)
Principal Investigator
Adelinda Yee
Project type
Capability Research
Most genomes are annotated based on sequence homology but there are many proteins encoded in the genome where the sequence do not have homology to other proteins with known functions and these are…

Structural Proteomics: annotating the genome using 3D structure

Lead Institution
University of Toronto
Principal Investigator
Cheryl Arrowsmith
Project type
Capability Research
We wish to understand protein biochemical function through the use of NMR spectroscopy and the derivation of solution structures from NMR data. The rationale for such an approach is that protein…

Structural Proteomics: annotating the genome using 3D structure

Lead Institution
University of Toronto
Principal Investigator
Cheryl Arrowsmith
Project type
Capability Research
We are applying for NMR spectrometer time at EMSL as a continuation of our structural proteomics project and to study two p53 interacting proteins. Structure of these proteins in complex with p53…

Structural Proteomics: annotating the genome using 3D structure

Lead Institution
University of Toronto
Principal Investigator
Cheryl Arrowsmith
Project type
Capability Research
We are applying for NMR spectrometer time at EMSL as a continuation of our structural ^M proteomics. Structural proteomics is based on the premise that a protein's biochemical function is ^M …

Structural Proteomics: annotating the genome using 3D structure

Lead Institution
University of Toronto
Principal Investigator
Cheryl Arrowsmith
Project type
Capability Research
We are applying for NMR spectrometer time at EMSL as a continuation of our structural ^M proteomics. Structural proteomics is based on the premise that a protein's biochemical function is ^M …

High-Throughput Structure Determination of Proteins and Protein Complexes

Lead Institution
Rutgers University
Principal Investigator
Gaetano Montelione
Project type
Large-Scale EMSL Research
The Northeast Structural Genomics Consortium (NESGC, www.nesg.org) is one of four large protein structure production centers supported by the NIH Protein Structure Initiative II (the PSI II). The…