Angela Norbeck

Development of the Integrated MetaPROteomics Viewer (IMPROV) Software Toolkit

Lead Institution

University of British Columbia

Principal Investigator

Steven Hallam

Project type

Scientific Partner

Beyond the periphery of our senses exists an infinitely diverse microbial world. This microcosm extends into every imaginable habitat, thrives under powerful extremes, and helps create and sustain…

Developing efficient fungal biocatalysts for on-site enzyme production and for production of chemical building blocks in biorefineries using metabolomic and secretomic profiling

Lead Institution

Aalborg University

Principal Investigator

Mette Lubeck

Project type

Large-Scale EMSL Research

Development of biocatalysts for sustainable production of bioactive molecules from lignocellulosic plant biomass in biorefineries is a rapid growing research area. One of the most important and…

Comparative metaproteomics and metametabolomics of the biomass-degrading microbial community that inhabits the cow rumen

Lead Institution

University of California, Davis

Principal Investigator

Matthias Hess

Project type

Large-Scale EMSL Research

Lignocellulosic plant material is one of the most promising sources of sustainable liquid transportation fuels but the recalcitrant nature of the plant cell wall and the cost of biomass-degrading…

Developing Ionic-Liquid Tolerant Enzymatic Cocktails for Lignocellulosic Biomass Deconstruction

Lead Institution

Lawrence Berkeley National Laboratory

Principal Investigator

Steven Singer

Project type

Large-Scale EMSL Research

The DOE Joint BioEnergy Institute (JBEI) is tasked with developing these advanced biofuels from lignocellulosic biomass. Part of this mission is to develop efficient methods to deconstruct biomass,…

Rhizosphere Research Campaign: The plant-soil interface - understanding dynamic interactions in the context of environmental change

Lead Institution

University of Missouri - Columbia

Principal Investigator

Gary Stacey

Project type

Research Campaign

The ultimate, long-term goal is to determine what drives source-sink relationships that control the cycling of plant nutrients belowground. To fully appreciate the complexities of this dynamic…

Microbial controls on climate active trace gas cycling in a model oxygen minimum zone

Lead Institution

University of British Columbia

Principal Investigator

Steven Hallam

Project type

Large-Scale EMSL Research

Dissolved oxygen (O2) concentration is a critical organizing principle within marine ecosystems. As oxygen levels decline, energy is increasingly diverted away from higher trophic levels into…

Global Proteomic Analysis of Human Ehrlichiosis Agents

Lead Institution

The Ohio State University

Principal Investigator

Yasuko Rikihisa

Project type

Large-Scale EMSL Research

Obligatory intracellular bacteria (belonging to Rickettsia): Ehrlichia chaffeensis and Anaplasma phagocytophilum cause potentially fatal emerging zoonoses: human monocytic ehrlichiosis and human…

Comparative Proteomic Analysis of Naturally Occurring Anaerobic Methane Oxidizing Communities

Lead Institution

University of British Columbia

Principal Investigator

Steven Hallam

Project type

Large-Scale EMSL Research

Methane is a potent greenhouse gas whose atmospheric concentration has increased significantly due to anthropogenic activities and fluctuated naturally over glacial and interglacial cycles. While…

Community Proteomic Analysis of a Near-Shore Anoxic Basin: Saanich Inlet

Lead Institution

University of British Columbia

Principal Investigator

Steven Hallam

Project type

Large-Scale EMSL Research

Oxygen minimum zones (OMZs; areas of low dissolved oxygen concentrations) play a major role in biogeochemical cycling within the world's oceans. They are major sinks for nitrogen and sources for…

Run ScalaBLAST on Proteomics Datasets

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Erich Vorpagel

This project is in support of the on going research within EMSL. As part of that support, MSCF computer time is being made available on an as-needed basis. The ultimate goal of high-throughput…

ScalaBLAST to reduce protein sequence redundancy, determine similarity among species, and enable proteomics on unsequenced microbial communities

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Angela Norbeck

Project type

Limited Scope

The ultimate goal of high-throughput proteomics centers such as that located at PNNL is the challenge of correctly identifying peptides (protein fragments) from biological samples based on their…

High-Throughput Proteomics: Applications and Development (PNNL Scope #40601 and #43488)

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Gordon Anderson

This project involves the application and development of high-throughput proteomics and quantitative measurement capabilities within biological systems. More so, application measurements will be…

High-throughput sequence analysis for communities and environmental sample metagenomics

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Christopher Oehmen

Project type

Capability Research

Metagenomes and multiple genome samples include environmental samples from soil and water, community samples involving multiple species (such as human or termite gut) and others. DOE has recognized…

Understanding Biomass Conversion within Thermophilic Communities and Isolates

Lead Institution

Lawrence Berkeley National Laboratory

Principal Investigator

Steven Singer

Project type

Large-Scale EMSL Research

Efficient deconstruction of lignocellulose into monomeric sugars is a key step in the development of renewable and sustainable liquid transportation fuels from biomass. The DOE Joint BioEnergy…

EMSL Science Overview

Angela Norbeck

Projects

Development of the Integrated MetaPROteomics Viewer (IMPROV) Software Toolkit

Developing efficient fungal biocatalysts for on-site enzyme production and for production of chemical building blocks in biorefineries using metabolomic and secretomic profiling

Comparative metaproteomics and metametabolomics of the biomass-degrading microbial community that inhabits the cow rumen

Developing Ionic-Liquid Tolerant Enzymatic Cocktails for Lignocellulosic Biomass Deconstruction

Rhizosphere Research Campaign: The plant-soil interface - understanding dynamic interactions in the context of environmental change

Microbial controls on climate active trace gas cycling in a model oxygen minimum zone

Global Proteomic Analysis of Human Ehrlichiosis Agents

Comparative Proteomic Analysis of Naturally Occurring Anaerobic Methane Oxidizing Communities

Community Proteomic Analysis of a Near-Shore Anoxic Basin: Saanich Inlet

Run ScalaBLAST on Proteomics Datasets

ScalaBLAST to reduce protein sequence redundancy, determine similarity among species, and enable proteomics on unsequenced microbial communities

High-Throughput Proteomics: Applications and Development (PNNL Scope #40601 and #43488)

High-throughput sequence analysis for communities and environmental sample metagenomics

Understanding Biomass Conversion within Thermophilic Communities and Isolates