Arzu Umar

Arzu Umar's Proposal
Identification of functional pathways associated with clinical tamoxifen-resistance in breast cancer by advanced mass spectrometry

Lead Institution

Erasmus University Medical Center, Rotterdam

Principal Investigator

Arzu Umar

Project type

Exploratory Research

Treatment of breast carcinomas with endocrine therapy is beneficial to patients until the point of therapy resistance is reached. In 50% of the cases resistance to endocrine therapy is intrinsic,…

Collaborative Research Projects Supported by the NCRR P41 Resource Center

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

David Camp

Project type

Large-Scale EMSL Research

The Proteomics Resource Center for Integrative Biology at PNNL was established in 2003 and builds on the unique instrumentation and the infrastructure provided by PNNLs EMSL facility. The mission of…

Phosphoproteomic profiling of breast cancer cell lines

Lead Institution

Erasmus University Medical Center, Rotterdam

Principal Investigator

Arzu Umar

Project type

Large-Scale EMSL Research

Breast cancer is a very heterogeneous disease, consisting of different molecular subtypes. Effective, targeted treatment is available for estrogen receptor (ER) and human epidermal growth factor…

Collaborative research projects in the PNNL NIH NCRR P41 Biomedical Technology Research Center 'Proteomics research resource for integrative biology'

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

David Camp

Collaborative research projects in the PNNL NIH NCRR P41 Biomedical Technology Research Center 'Proteomics research resource for integrative biology'

Looking for Partners in Crime: Identification of Protein Complexes and Post-Translational Modifications Associated with Drug-Resistance in Breast Cancer

Lead Institution

Erasmus University Medical Center, Rotterdam

Principal Investigator

Arzu Umar

Project type

Large-Scale EMSL Research

Drug resistance of metastatic tumor cells is the major cause of death in breast cancer patients. Through a previous EMSL collaboration, EMMPRIN (extracellular matrix metalloproteinase inducer) was…

Identification of functional pathways associated with clinical tamoxifen-resistance in breast cancer by advanced mass spectrometry

Lead Institution

Erasmus University Medical Center, Rotterdam

Principal Investigator

Arzu Umar

Project type

Exploratory Research

There is a need to identify specific target proteins that may lead to newly-designed drugs, and individual treatment strategies for patients with (advanced) breast cancer. In particular, the…

Identification and Validation of Protein Profiles Associated with Therapy-Resistance in Breast Cancer

Lead Institution

Erasmus University Medical Center, Rotterdam

Principal Investigator

Arzu Umar

Project type

Large-Scale EMSL Research

Successful treatment of breast cancer is hampered by the occurrence of drug resistance in approximately 50% of patients with advanced recurrent disease. The ultimate goal of proposed work is to…