Bhaskar Paidimuddala

Collaborative Access Team: Pacific Northwest Cryo-EM Center (PNCC)

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

James Evans

PNNL will create and operate the Pacific Northwest Center for Cryo-EM (PNCC), a state-of-the-art national center for cryo-electron microscopy (Cryo-EM) that will rapidly and efficiently collect and…

Understanding the structural basis of RFX complex in regulating MHC gene expression

Lead Institution

Oregon Health & Science University

Principal Investigator

Liman Zhang

The Major Histocompatibility complex (MHC) is critical in immune system for T cell maturation and self vs nonself discrimination, thus expression of MHC genes has to be tightly regulated. Active…

Understanding the structural basis of NLR proteins in regulating MHC gene expression

Lead Institution

Oregon Health & Science University

Principal Investigator

Liman Zhang

Class II transcription activator (CIITA) is immunologically critical for T cell maturation as it regulates the Major Histocompatibility Complex class II (MHC-II) gene expression. Unlike the other…

CryoEM study of NLR proteins in the immune regulation

Lead Institution

Oregon Health & Science University

Principal Investigator

Liman Zhang

Nucleotide-binding domain and leucine rich repeat containing (NLR) proteins comprise a fascinating family that plays key roles in regulating immune signal transduction: they initiate inflammation in…

EMSL Science Overview

Bhaskar Paidimuddala

Projects

Collaborative Access Team: Pacific Northwest Cryo-EM Center (PNCC)

Understanding the structural basis of RFX complex in regulating MHC gene expression

Understanding the structural basis of NLR proteins in regulating MHC gene expression

CryoEM study of NLR proteins in the immune regulation