Chad Rienstra

Determine 3d-structure of chemokine in apo form and in complex with its native receptor by solid state NMR

Lead Institution

Bristol-Myers Squibb

Principal Investigator

Luciano Mueller

Project type

Large-Scale EMSL Research

Structural biology has significantly accelerated the development of drug leads in protein targets for which 3d structures could be obtained either by XRAY crystallography or by NMR spectroscopy…

Structure and Function of Macromolecular Complexes by Multidimensional High-Field Magic-Angle Spinning NMR

Lead Institution

University of Illinois at Urbana-Champaign

Principal Investigator

Chad Rienstra

Project type

Large-Scale EMSL Research

We aim to explore the limits of performance for high-field (900 MHz) magic-angle spinning NMR studies of non-crystalline solid proteins, in order to solve high-resolution structures of macromolecular…

Multidimensional High-Field Magic-Angle Spinning NMR of Membrane and Nanocrystalline Proteins

Lead Institution

University of Illinois at Urbana-Champaign

Principal Investigator

Chad Rienstra

Project type

Capability Research

We aim to extend ongoing studies of membrane protein structure at the University of Illinois, conducted on 500 and 750 MHz instruments in 3.2 mm magic-angle spinning rotors, to the 900 MHz BioSolids…

Determine 3d-structure of chemokine in apo form and in complex with its native receptor by solid state NMR

Lead Institution

Bristol-Myers Squibb

Principal Investigator

Luciano Mueller

Project type

Exploratory Research

Structural biology has significantly accelerated the development of drug leads in protein targets for which 3d structures could be obtained either by XRAY crystallography or by NMR spectroscopy…

Multidimensional High-Field Magic-Angle Spinning NMR
of Membrane and Nanocrystalline Proteins

Lead Institution

University of Illinois at Urbana-Champaign

Principal Investigator

Chad Rienstra

Project type

Large-Scale EMSL Research

We aim to extend ongoing studies of membrane and fibril protein structure at the University of Illinois, conducted on 500 and 750 MHz instruments in 3.2 mm magic-angle spinning rotors, to the 900 MHz…

EMSL Science Overview

Chad Rienstra

Projects

Determine 3d-structure of chemokine in apo form and in complex with its native receptor by solid state NMR

Structure and Function of Macromolecular Complexes by Multidimensional High-Field Magic-Angle Spinning NMR

Multidimensional High-Field Magic-Angle Spinning NMR of Membrane and Nanocrystalline Proteins

Determine 3d-structure of chemokine in apo form and in complex with its native receptor by solid state NMR

Multidimensional High-Field Magic-Angle Spinning NMR
of Membrane and Nanocrystalline Proteins