Christopher Anderton

Development and refinement of an in situ 'molecular microscope' utilizing ultrahigh resolution mass spectrometry

Lead Institution

University of Missouri - Columbia

Principal Investigator

Gary Stacey

The ability to elucidate complex metabolic behavior of living organisms in situ and with cellular resolution is a bioanalytical grand challenge that is yet to be realized. Mass spectrometry imaging …

Advancement of the molecular microscope to enable high-resolution dynamic imaging and unprecedented spatial metabolomic information of living systems

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Christopher Anderton

The ability to capture and visualize the complex metabolic behavior of living organisms in situ is a bioanalytical grand challenge that has yet to be fully realized. Ambient ionization mass…

Quantifying the functional and structural states of dynamic microbial communities

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

James Fredrickson

Project type

Large-Scale EMSL Research

The overall goal of this proposal is to provide a quantitative framework in which to compare species-resolved patterns of gene expression, allowing comparison of the effects of perturbations of…

Carbon Sequestration Beneath the Active Zone of the Rhizosphere: Insights from Extremophile Ecosystems

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Sherry Cady

To better understand the ultimate fate of carbon sequestered in the subsurface, we are studying carbon sequestration mechanisms in mineralizing extremophile environments. Such ecosystems provide an…

Targeted spatial metabolomics: an automated approach to identifying and analyzing single cells in situ

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Christopher Anderton

Tissue-scale or cell-population-level analysis (i.e., ‘bulk analysis’) yields averaged abundance data that can mask critical information about the state of individual cells. Through a recently ended…

EMSL Science Overview

Christopher Anderton

Projects

Development and refinement of an in situ 'molecular microscope' utilizing ultrahigh resolution mass spectrometry

Advancement of the molecular microscope to enable high-resolution dynamic imaging and unprecedented spatial metabolomic information of living systems

Quantifying the functional and structural states of dynamic microbial communities

Carbon Sequestration Beneath the Active Zone of the Rhizosphere: Insights from Extremophile Ecosystems

Targeted spatial metabolomics: an automated approach to identifying and analyzing single cells in situ