Craig Yoshioka

Collaborative Access Team: Pacific Northwest Cryo-EM Center (PNCC)

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

James Evans

PNNL will create and operate the Pacific Northwest Center for Cryo-EM (PNCC), a state-of-the-art national center for cryo-electron microscopy (Cryo-EM) that will rapidly and efficiently collect and…

Structural characterization of TRPA1 ion channel in complex with selective agonists

Lead Institution

Genentech, Inc.

Principal Investigator

Alexis Rohou

Our aim is to determine the structures of agonists bound to TRPA1, a ligand-gated ion channel and polymodal receptor implicated in pain, itch and respiratory diseases. Electrophilic agonists, such…

Transcription initiation in the context of chromatin

Lead Institution

University of California, Berkeley

Principal Investigator

Eva Nogales

The genetic information of eukaryotic cells is packaged into dense chromatin, which comes in the form of nucleosome arrays. Access to specific genomic sites requires that nucleosomes are remodeled to…

Transcription initiation in the context of chromatin

Lead Institution

University of California, Berkeley

Principal Investigator

Eva Nogales

The genetic information of eukaryotic cells is packaged into dense chromatin, which comes in the form of nucleosome arrays. Access to specific genomic sites requires that nucleosomes are remodeled to…

EMSL Science Overview

Craig Yoshioka

Projects

Collaborative Access Team: Pacific Northwest Cryo-EM Center (PNCC)

Structural characterization of TRPA1 ion channel in complex with selective agonists

Transcription initiation in the context of chromatin

Transcription initiation in the context of chromatin