Dana Lacy

Vanderbilt University Medical Center

0000-0003-2273-8121

Projects

Collaborative Access Team: Pacific Northwest Cryo-EM Center (PNCC)

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

James Evans

PNNL will create and operate the Pacific Northwest Center for Cryo-EM (PNCC), a state-of-the-art national center for cryo-electron microscopy (Cryo-EM) that will rapidly and efficiently collect and…

Cryo-EM Analysis of TcdB in Complex with Host Cell Receptors

Lead Institution

Vanderbilt University Medical Center

Principal Investigator

Dana Lacy

Clostridioides difficile infection (CDI) is responsible for the majority of hospital acquired diarrhea cases reported in the United States. The pathology of CDI relies on the activity of three…

Cryo-EM analysis of the C. perfringens toxin TpeL with its host cell receptor LRP1

Lead Institution

Vanderbilt University Medical Center

Principal Investigator

Dana Lacy

Clostridioides difficile infection is often activated by alterations in the gut microbiota through antibiotic use, and recurrent infections are associated with severe clinical outcomes. Pathogenesis…