David Stenoien

Transcriptional and epigenetic regulation following ionizing radiation exposure in a skin model system

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

David Stenoien

Project type

Exploratory Research

Dynamic post-translational modifications (PTMs) occurring on histones play essential roles in regulating transcription of specific target genes and in the epigenetic reprogramming occurring during…

Integrating intact protein proteomics with ChIP-Seq for identification and functional characterization of epigenetic histone modifications

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

David Stenoien

Project type

Large-Scale EMSL Research

Biological systems are exceedingly more complex than defined by the genome due to differential protein expression and degradation, altered mRNA splicing, and the presence of multiple post…

Identification of radiation affected histone modifications.

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

David Stenoien

Biological systems are exceedingly more complex than defined by the genome due to differential protein expression and degradation, altered mRNA splicing, and the presence of multiple post…

Identification and post-translational modification of mitotic regulatory proteins.

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

David Stenoien

Project type

Exploratory Research

This project will be conducted as an NCRR collaborative project. This study is designed to identify novel chromosomal passenger (CP) proteins and their post-translational modifications. CPs…

Characterization of Signaling Events Induced by Low Dose Ionizing Radiation

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

David Stenoien

Project type

Scientific Partner

Exposure to low doses of radiation has the potential to adversely affect human health but the actual health risks and the underlying molecular mechanisms associated with these risks are still poorly…

Collaborative Research Projects Supported by the NCRR P41 Resource Center

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

David Camp

Project type

Large-Scale EMSL Research

The Proteomics Resource Center for Integrative Biology at PNNL was established in 2003 and builds on the unique instrumentation and the infrastructure provided by PNNLs EMSL facility. The mission of…

Integrated top-down and bottom-up proteomics strategy to identify multisite and multistep modifications on radiation sensitive proteins

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

David Stenoien

Project type

Large-Scale EMSL Research

In order for a cell to mount the appropriate response to a stimulus such as radiation, it must have the necessary biosensors capable of assessing inputs from multiple intracellular and extracellular…

An integrated workflow for identification and quantitation of intact phosphoproteins

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Ljiljana Pasa-Tolic

Multisite protein modifications involving phosphorylation alone or in combination with other post-translational modifications (PTMs) play an essential role in regulating protein activity. Hence,…

Collaborative research projects in the PNNL NIH NCRR P41 Biomedical Technology Research Center 'Proteomics research resource for integrative biology'

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

David Camp

Collaborative research projects in the PNNL NIH NCRR P41 Biomedical Technology Research Center 'Proteomics research resource for integrative biology'