Erkan Karakas

Collaborative Access Team: Pacific Northwest Cryo-EM Center (PNCC)

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

James Evans

PNNL will create and operate the Pacific Northwest Center for Cryo-EM (PNCC), a state-of-the-art national center for cryo-electron microscopy (Cryo-EM) that will rapidly and efficiently collect and…

Structural characterization of inositol triphosphate receptors

Lead Institution

Vanderbilt University

Principal Investigator

Erkan Karakas

The overall goal of the research studies proposed here is to structurally characterize the inositol 1,4,5-triphosphate (IP3) receptors (IP3Rs). IP3Rs are tetrameric intracellular Ca2+ channels that…

Cryo-EM structural analysis of Glucose-6-phosphatase catalytic subunit, G6PC1

Lead Institution

Vanderbilt University

Principal Investigator

Hassane Mchaourab

The catalytic subunit of glucose-6-phosphatase, G6PC1, functions as a gatekeeper of glucose production in the liver by catalyzing the hydrolysis of glucose-6-phosphate. Dysregulation of G6PC1 gene…

Structural characterization of inositol 1,4,5-triphosphate receptors

Lead Institution

Vanderbilt University

Principal Investigator

Erkan Karakas

Inositol 1,4,5-triphosphate receptors (IP3Rs) function as signaling hubs integrating diverse signals to regulate many physiological processes. Pathological dysregulation of IP3Rs and calcium…

EMSL Science Overview

Erkan Karakas

Projects

Collaborative Access Team: Pacific Northwest Cryo-EM Center (PNCC)

Structural characterization of inositol triphosphate receptors

Cryo-EM structural analysis of Glucose-6-phosphatase catalytic subunit, G6PC1

Structural characterization of inositol 1,4,5-triphosphate receptors