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Farzad Jalali-Yazdi

Institution
Oregon Health & Science University
ORCID
ORCID logo 0000-0002-0291-3482

Projects

Structure and mechanism of neurotransmitter-gated ion channels

Lead Institution
Oregon Health & Science University
Principal Investigator
Eric Gouaux
The objectives of this research are to elucidate the structures of mammalian neurotransmitter receptors by single particle cryo-EM in multiple distinct conformational states in which the receptors…

Obtaining the open-pore conformation of the NMDA receptor

Lead Institution
Oregon Health & Science University
Principal Investigator
Eric Gouaux
NMDA receptors (NMDARs) are responsible for the fast-component of the excitatory neurotransmission in the central nervous system, along with AMPA receptors. These receptors have a unique and…

Structure and activation mechanism of TMEM206

Lead Institution
Oregon Health & Science University
Principal Investigator
Eric Gouaux
Proton activated channels are ion-permeable channels that are rapidly activated by extracellular acidification. With their activation levels falling well below physiological pH, these channels…