Identifying the immunogenic epitopes implicated in Anti-NMDA receptor encephalitis
EMSL Project ID
51316
Abstract
NMDA receptors are a member of the ionotropic glutamate receptor family, responsible for transmission of the main component of the fast excitatory neurotransmission in the central nervous system. Anti-NMDA receptor encephalitis is an autoimmune disorder in which antibodies are generated that target this receptor, leading to the internalization and removal of the NMDA receptor from neuronal membranes. Thy symptoms of this disorder include psychosis, agitation, seizures, and ultimately death if the disorder is left untreated. Here we propose to use antibodies from mice with anti-NMDAR encephalitis to elucidate the epitopes that are targeted by the immune system. Mapping the most antigenic NMDAR epitopes is essential for understanding the progression of anti-NMDAR encephalitis, and is the first step in developing targeted therapeutics designed to block those epitopes.
Project Details
Start Date
2020-05-05
End Date
2021-03-17
Status
Closed
Released Data Link
Team
Principal Investigator
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