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Eric Gouaux

Institution
Oregon Health & Science University
ORCID
ORCID logo 0000-0002-8549-2360

Projects

Structure and activation mechanism of mammalian prestin

Lead Institution
Oregon Health & Science University
Principal Investigator
Eric Gouaux
The mammalian cochlear hair cells are the sensory receptors for the auditory system. They consist of one row of inner hair cells (IHCs) and three rows of outer hair cells (OHCs) with stereocilia on…

Structure and activation mechanism of TMEM206

Lead Institution
Oregon Health & Science University
Principal Investigator
Eric Gouaux
Proton activated channels are ion-permeable channels that are rapidly activated by extracellular acidification. With their activation levels falling well below physiological pH, these channels…

Elucidating the structure of C. elegans TMC1 and TMC2

Lead Institution
Oregon Health & Science University
Principal Investigator
Eric Gouaux
Transmembrane channel-like (TMC) proteins are a unique family of channel-like proteins that are conserved from humans to C. elegans. Vertebrates express eight isoforms, two of which are essential for…

Cryo-electron tomography of glutamatergic synapses

Lead Institution
Oregon Health & Science University
Principal Investigator
Eric Gouaux
Ionotropic glutamate-receptor ion channels (iGluRs) are the major mediators of excitatory synaptic transmission that couple glutamate release to depolarization of postsynaptic neurons in the central…

Collaborative Access Team: Pacific Northwest Cryo-EM Center (PNCC)

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
James Evans
PNNL will create and operate the Pacific Northwest Center for Cryo-EM (PNCC), a state-of-the-art national center for cryo-electron microscopy (Cryo-EM) that will rapidly and efficiently collect and…

Structure and mechanism of neurotransmitter-gated ion channels

Lead Institution
Oregon Health & Science University
Principal Investigator
Eric Gouaux
The objectives of this research are to elucidate the structures of mammalian neurotransmitter receptors by single particle cryo-EM in multiple distinct conformational states in which the receptors…

Cryo-EM studies of the human biogenic amine transporters

Lead Institution
Oregon Health & Science University
Principal Investigator
Eric Gouaux
The aims of the proposed research are to elucidate the first structure of the human dopamine transporter (hDAT) as well as to determine multiple structures of the human serotonin transporter (hSERT)…

Structure of an acid-sensing ion channel in a lipid environment.

Lead Institution
Oregon Health & Science University
Principal Investigator
Eric Gouaux
Acid-sensing ion channels (ASICs) are voltage-insensitive and proton-gated members of the Na-selective epithelial sodium channel/degenerin (ENaC/DEG) superfamily of ion channels and are expressed…

Obtaining the open-pore conformation of the NMDA receptor

Lead Institution
Oregon Health & Science University
Principal Investigator
Eric Gouaux
NMDA receptors (NMDARs) are responsible for the fast-component of the excitatory neurotransmission in the central nervous system, along with AMPA receptors. These receptors have a unique and…

Architecture of native protocadherin-15 in complex with LHFPL5

Lead Institution
Oregon Health & Science University
Principal Investigator
Eric Gouaux
Mechanotransduction machinery located at the tips of hair bundles in the inner ear are responsible for our sensations of movement and sound. Each bundle is composed of stereocilia that are connected…