Michael Lewis

Combining Proteomic Technologies to Create a Platform for Spatiotemporal Enzyme Activity Profiling

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Susan Wiedner

There is a need to investigate the functional activity of enzymes on the subcellular level to increase the understanding of a multitude of biological processes and protein interactions. The…

Genome-Enabled Studies of Photosynthetic Microorganisms for Bioenergy Applications - Chemical Protein Profiling

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Aaron Wright

As part of PNNL's Scientific Focus Area "Genome-Enabled Studies of Photosynthetic Microorganisms for Bioenergy Applications" this project is applying and developing click-chemistry…

Regulatory dynamics of microbial communities

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

H Wiley

Project type

Large-Scale EMSL Research

This is a proposal to conduct work in EMSL in support of the Foundational Scientific Focus Area (FSFA) research program at Pacific Northwest National Laboratory. This large-scale research program…

Identification of Functional Proteins Relevant to Bioenergy and Disease Pathology by Multiplexed Activity-Based Protein Profiling

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Aaron Wright

Develop multiplexed activity-based protein profiling and apply to identification of P450s in Mycobacterium tuberculosis and biomarkers in Aspergillus fumigatus. Additionally the technology will be…

EMSL Science Overview

Michael Lewis

Projects

Combining Proteomic Technologies to Create a Platform for Spatiotemporal Enzyme Activity Profiling

Genome-Enabled Studies of Photosynthetic Microorganisms for Bioenergy Applications - Chemical Protein Profiling

Regulatory dynamics of microbial communities

Identification of Functional Proteins Relevant to Bioenergy and Disease Pathology by Multiplexed Activity-Based Protein Profiling