Natalie Strynadka

COVID-19: Structural characterization of the evolution pathways of SARS-CoV-2 viral spike protein

Lead Institution

University of British Columbia

Principal Investigator

Natalie Strynadka

The ongoing COVID-19 epidemic represents a global public health crisis unseen in recent memory. The virion surface glycoprotein known as spike is a trimeric extension that mediates both the initial…

Structural characterization of the type III secretion system using cryo electron tomography and single particle analysis

Lead Institution

University of British Columbia

Principal Investigator

Natalie Strynadka

Type III Secretion Systems (T3SS) are multiprotein, syringe-shaped nanomachines that deliver virulence factors, known as effector proteins, from bacteria into host cells. T3SS are common in Gram…

Structure and function of an ancestral acetyl-CoA carboxylase

Lead Institution

University of British Columbia

Principal Investigator

Natalie Strynadka

Acetyl-CoA carboxylase (ACC) is a biotin-dependent enzyme that catalyzes the first committed step in lipid biosynthesis in Bacteria and Eukarya. We aim to characterize AccM, an ACC from an oleaginous…

Collaborative Access Team: Pacific Northwest Cryo-EM Center (PNCC)

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

James Evans

PNNL will create and operate the Pacific Northwest Center for Cryo-EM (PNCC), a state-of-the-art national center for cryo-electron microscopy (Cryo-EM) that will rapidly and efficiently collect and…

PNCC Standard Access - Structural insights into bacterial divisome "Fts" proteins

Lead Institution

University of British Columbia

Principal Investigator

Natalie Strynadka

Our vision is to develop and use structural biology methods to characterize membrane-associated protein assemblies relevant to antibiotic resistance and bacterial pathogenicity. We aim to illuminate…

PNCC General Access - Structure-based antibiotic discovery on the bacterial membrane – Penicillin-binding proteins (PBPs)

Lead Institution

University of British Columbia

Principal Investigator

Natalie Strynadka

Our vision is to develop and use structural biology methods to characterize membrane-associated protein assemblies relevant to antibiotic resistance and bacterial pathogenicity. We aim to illuminate…

Structural characterization of BlaR1: A key regulator of beta-lactam resistance in Staphylococcus aureus

Lead Institution

University of British Columbia

Principal Investigator

Natalie Strynadka

Our vision is to develop and use structural biology methods to characterize membrane-associated protein assemblies relevant to antibiotic resistance and bacterial pathogenicity. We are particularly…

Structure and function of an ancestral acetyl-CoA carboxylase

Lead Institution

University of British Columbia

Principal Investigator

Natalie Strynadka

Acetyl-CoA carboxylase (ACC) is a biotin-dependent enzyme that catalyzes the first committed step in lipid biosynthesis in Bacteria and Eukarya. We aim to characterize AccM, an ACC from an oleaginous…

Structural characterization of essential enzymes in bacterial wall teichoic acid biogenesis

Lead Institution

University of British Columbia

Principal Investigator

Natalie Strynadka

Wall teichoic acid (WTA) is a Gram-positive bacterial cell wall polymer with roles in host cell adherence and coordination of essential physiological processes including cell division and…

EMSL Science Overview

Natalie Strynadka

Projects

COVID-19: Structural characterization of the evolution pathways of SARS-CoV-2 viral spike protein

Structural characterization of the type III secretion system using cryo electron tomography and single particle analysis

Structure and function of an ancestral acetyl-CoA carboxylase

Collaborative Access Team: Pacific Northwest Cryo-EM Center (PNCC)

PNCC Standard Access - Structural insights into bacterial divisome "Fts" proteins

PNCC General Access - Structure-based antibiotic discovery on the bacterial membrane – Penicillin-binding proteins (PBPs)

Structural characterization of BlaR1: A key regulator of beta-lactam resistance in Staphylococcus aureus

Structure and function of an ancestral acetyl-CoA carboxylase

Structural characterization of essential enzymes in bacterial wall teichoic acid biogenesis