Pietro Fontana

Boston Children's Hospital

0000-0003-3215-3784

Projects

COVID-19: Structural study of RNA-dependent RNA polymerase of SARS-CoV-2

Lead Institution

Boston Children's Hospital

Principal Investigator

Hao Wu

The outbreak of COVID-19 by SARS-CoV-2 infection has induced a global health crisis with millions of infections and about 20 thousand deaths. The replication of SARS-CoV-2 is dependent on RNA…

Collaborative Access Team: Pacific Northwest Cryo-EM Center (PNCC)

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

James Evans

PNNL will create and operate the Pacific Northwest Center for Cryo-EM (PNCC), a state-of-the-art national center for cryo-electron microscopy (Cryo-EM) that will rapidly and efficiently collect and…

Novel serine peptidases regulate the NLRP1 and CARD8 inflammasomes

Lead Institution

Boston Children's Hospital

Principal Investigator

Hao Wu

The inflammatory response provides an absolutely essential host defense mechanism that, if perturbed, can itself cause a large number of human diseases. Collectively, innate immune responses…