Sankarganesh Krishnamoorthy

Development of chemical probes for live cell Raman imaging

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Sankarganesh Krishnamoorthy

Biological molecular phenotyping requires characterization tools that can record multiple biological processes and molecular transformations simultaneously in real time. Currently, fluorescence…

Mapping microbial transporters with small molecule fluorescent probes

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Erin Bredeweg

Objectives: There is a gap in our ability to measure transport of cell materials (sugars, lipids, amino acids, metabolites, cofactors, etc.) across membranes, and to observe transporter localization…

Activity-based probes (ABPs) for studying the molecular mechanism of root exudation

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Vimal Kumar Balasubramanian

Evolving a symbiotic plant-microbe relationship in the rhizosphere (root-soil interface) is essential for sustainable bioenergy feedstock production. Such a relationship is facilitated by plant small…

High throughput generation of small molecule probes for discovery of unique cellular functions using Substrate Activity Screening

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Sankarganesh Krishnamoorthy

We propose a method to demystify the massive catalog of proteins-of-unknown-function accumulated by recent advances in genome sequencing by direct assignment of function. We will query enzyme…

Nanopore Platforms for Protein Analysis

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Jayde Aufrecht

Nanopore-based protein sensing has the potential to revolutionize the field of proteomics by providing single-molecule protein sequencing at amino acid level resolution. However, even if nanopore…

EMSL Science Overview

Sankarganesh Krishnamoorthy

Projects

Development of chemical probes for live cell Raman imaging

Mapping microbial transporters with small molecule fluorescent probes

Activity-based probes (ABPs) for studying the molecular mechanism of root exudation

High throughput generation of small molecule probes for discovery of unique cellular functions using Substrate Activity Screening

Nanopore Platforms for Protein Analysis