Theo Luider

Top-down proteomics analysis of the antigen binding region of IgG to detect antigen-specific sequences that are shared between individuals

Lead Institution

Erasmus University Medical Center, Rotterdam

Principal Investigator

Theo Luider

Project type

Limited Scope

Autoantibodies play an important role in the diagnosis of cancer and autoimmune diseases and are increasingly used as biomarkers in the early detection of cancer. Disease specific antibodies,…

An integrated top-down / bottom-up method to identify disease related antibodies

Lead Institution

Erasmus University Medical Center, Rotterdam

Principal Investigator

Theo Luider

Project type

Exploratory Research

We describe the discovery of a new class of biomarkers derived from immunoglobulins using mass spectrometry. We previously investigated this approach in model systems with bottom-up proteomics, and…

Molecular imaging of amyloid beta peptide in the Alzheimer brain

Lead Institution

Erasmus University Medical Center, Rotterdam

Principal Investigator

Theo Luider

Project type

Limited Scope

The amyloid plaque is a principal pathological hallmark of the Alzheimer disease (AD) brain. Amyloid plaques are extracellular accumulations composed of the amyloid beta (Abeta) peptide and…

An integrated top-down and bottom-up proteomics approach to characterize antibodies

Lead Institution

Erasmus University Medical Center, Rotterdam

Principal Investigator

Leendert Dekker

Project type

Limited Scope

We describe the application of a new antibody based biomarker discovery approach by mass spectrometry. We previously investigated this approach, and by using different model systems evidence was…

Identification of functional pathways associated with clinical tamoxifen-resistance in breast cancer by advanced mass spectrometry

Lead Institution

Erasmus University Medical Center, Rotterdam

Principal Investigator

Arzu Umar

Project type

Exploratory Research

There is a need to identify specific target proteins that may lead to newly-designed drugs, and individual treatment strategies for patients with (advanced) breast cancer. In particular, the…

Identification and Validation of Protein Profiles Associated with Therapy-Resistance in Breast Cancer

Lead Institution

Erasmus University Medical Center, Rotterdam

Principal Investigator

Arzu Umar

Project type

Large-Scale EMSL Research

Successful treatment of breast cancer is hampered by the occurrence of drug resistance in approximately 50% of patients with advanced recurrent disease. The ultimate goal of proposed work is to…

EMSL Science Overview

Theo Luider

Projects

Top-down proteomics analysis of the antigen binding region of IgG to detect antigen-specific sequences that are shared between individuals

An integrated top-down / bottom-up method to identify disease related antibodies

Molecular imaging of amyloid beta peptide in the Alzheimer brain

An integrated top-down and bottom-up proteomics approach to characterize antibodies

Identification of functional pathways associated with clinical tamoxifen-resistance in breast cancer by advanced mass spectrometry

Identification and Validation of Protein Profiles Associated with Therapy-Resistance in Breast Cancer