William Catterall

University of Washington

0000-0001-5509-3580

Projects

Cryo-EM Studies of the Cardiac Sodium Channel and Antiarrhythmic Drugs

Lead Institution

University of Washington

Principal Investigator

Michael Lenaeus

We plan to use cryo-EM to study the cardiac sodium channel Nav1.5 and describe its antiarrhythmic drug receptor in molecular detail. The proposed cryo-EM studies will make use of PNNL’s cutting-edge…

Proteomics of Membrane Protein Complexes

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Diana Bigelow

Project type

Exploratory Research

A comprehensive understanding of the effects of cellular stress on calcium signaling requires correlated measurements of intracellular calcium transients and global proteomic analysis of both calcium…