Yuan He

Northwestern University

0000-0002-1455-3963

Projects

Toward the visualization of eukaryotic transcription machineries by cryo-EM

Lead Institution

Northwestern University

Principal Investigator

Yuan He

Eukaryotic genomes are modulated by different types of chromatin remodeling complexes and transcribed by multiple RNA polymerases. Of the three polymerases, Pol I-III, that produce RNA required for…

Collaborative Access Team: Pacific Northwest Cryo-EM Center (PNCC)

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

James Evans

PNNL will create and operate the Pacific Northwest Center for Cryo-EM (PNCC), a state-of-the-art national center for cryo-electron microscopy (Cryo-EM) that will rapidly and efficiently collect and…

Toward the visualization of NHEJ DNA repair machineries by cryo-EM

Lead Institution

Northwestern University

Principal Investigator

Yuan He

Among all different types of DNA damages, double strand breaks (DSBs) are viewed as the most toxic ones that lead to genome instability. Non-homologous end-joining (NHEJ) pathway, in which the two…