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NMR Structural Investigations of BRCA1

EMSL Project ID
2034
Award DOI
https://dx.doi.org/10.46936/cpbl.proj.2000.2034/60002698

Abstract

Recent identification of the breast and ovarian cancer susceptibility gene, BRCA1, promises to generate a wealth of information concerning breast and ovarian cancer cell biology.

Project Details

Project type
Capability Research
Start Date
2000-10-18
End Date
2000-11-28
Status
Closed
Released Data Link
https://search.emsl.pnnl.gov/?project_id_search=2034

Team

Principal Investigator

Rachel Klevit
Institution
University of Washington

Team Members

Peter Brzovic
Institution
University of Washington

Related Publications

Brzovic PS, JR Keeffe, H Nishikawa, K Miyamoto, D Fox, M Fukuda, T Ohta, and RE Klevit. 2003. "Binding and Recognition in the Assembly of an Active BRCA1/BARD1 Ubiquitin-Ligase Complex ." Proceedings of the National Academy of Sciences of the United States of America 100(10):5646-5651.
Brzovic PS, P Rajagopal, DW Hoyt, MC King, and RE Klevit. 2001. "Structure of a BRCA1/BARD1 Complex: a Heterodimeric RING-RING Interaction." Nature Structural Biology 8(10):833-837..