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Rachel Klevit

Institution
University of Washington

Projects

NMR Structural Investigations of BRCA1

Lead Institution
University of Washington
Principal Investigator
Rachel Klevit
Project type
Capability Research
This project is aimed at gaining structural insights into the biological function and dysfunction of the breast cancer susceptibility protein known as BRCA1. Though the biological role of BRCA1 is…

NMR Structural Investigations of BRCA1

Lead Institution
University of Washington
Principal Investigator
Rachel Klevit
Project type
Capability Research
The breast and ovarian cancer tumor suppressor protein, BRCA1, supports a number of fundamental cellular processes. Its absence during embryogenesis is lethal. Loss of function in proliferating…

NMR Structural Investigations of BRCA1

Lead Institution
University of Washington
Principal Investigator
Rachel Klevit
Project type
Capability Research
The breast and ovarian cancer tumor suppressor protein, BRCA1, supports a number of fundamental cellular processes. Its absence during embryogenesis is lethal. Loss of function in proliferating…

NMR Structural Investigations of BRCA1

Lead Institution
University of Washington
Principal Investigator
Rachel Klevit
Project type
Capability Research
The breast and ovarian cancer tumor suppressor protein, BRCA1, supports a number of fundamental cellular processes. Its absence during embryogenesis is lethal. Loss of function in proliferating…

Mechanisms of Ubiquitin Transfer and Regulation

Lead Institution
University of Washington
Principal Investigator
Rachel Klevit
Project type
Large-Scale EMSL Research
Protein ubiquitination is a powerful regulatory process that influences nearly every aspect of eukaryotic cell biology. Pathways ranging from cell-cycle progression and differentiation to DNA repair…

NMR Structural Investigations of BRCA1

Lead Institution
University of Washington
Principal Investigator
Rachel Klevit
Project type
Capability Research
The breast and ovarian cancer tumor suppressor protein, BRCA1, supports a number of fundamental cellular processes. Its absence during embryogenesis is lethal. Loss of function in proliferating…

alphaB-crystallin - the core and the Oligomer : A Structural Investigation

Lead Institution
University of Washington
Principal Investigator
Ponni Rajagopal
Project type
Capability Research
alphaB-crystallin (alphaB) belongs to the family of small heat shock proteins (sHSPs) and has been shown in vitro to be a molecular chaperone. It is one of the proteins essential for maintaining eye…

NMR Structural Investigations of BRCA1

Lead Institution
University of Washington
Principal Investigator
Rachel Klevit
Project type
Capability Research
The breast and ovarian cancer tumor suppressor protein, BRCA1, supports a number of fundamental cellular processes. Its absence during embryogenesis is lethal. Loss of function in proliferating…

Structural Investigation of a Molecular Chaperone

Lead Institution
University of Washington
Principal Investigator
Ponni Rajagopal
Project type
Capability Research
?B-Crystallin (?B) belongs to the family of small heat shock proteins (sHSPs) and has been shown in vitro to be a molecular chaperone. It is one of the proteins essential for maintaining eye-lens…

NMR Structural Investigations of BRCA1

Lead Institution
University of Washington
Principal Investigator
Rachel Klevit
Project type
Capability Research
The breast and ovarian cancer tumor suppressor protein, BRCA1, supports a number of fundamental cellular processes. Its absence during embryogenesis is lethal. Loss of function in proliferating…

Structural Investigation of alphaB-Crystallin Core Domains

Lead Institution
University of Washington
Principal Investigator
Ponni Rajagopal
Project type
Capability Research
Small Heat Shock Proteins (sHSPs) are ubiquitous cellular proteins that are over-expressed under conditions of stress in various organisms from bacteria to humans. ?B-Crystallin (?B), considered the…

NMR Structural Investigations of BRCA1

Lead Institution
University of Washington
Principal Investigator
Rachel Klevit
Project type
Capability Research
The breast and ovarian cancer tumor suppressor protein, BRCA1, supports a number of fundamental cellular processes. Its absence during embryogenesis is lethal. Loss of function in proliferating…

NMR Structureal Investigations of BRCA1

Lead Institution
University of Washington
Principal Investigator
Rachel Klevit
Project type
Capability Research
The next stage in structure determination of the BRCA1/BARD1 heterodimer complex requires the assignment of aliphatic side chain H-1 and C-13 resonances. Typically, HCCH-TOCSY experiments on fully…

NMR Structural Investigations of BRCA1

Lead Institution
University of Washington
Principal Investigator
Rachel Klevit
Project type
Capability Research
The breast and ovarian cancer tumor suppressor protein, BRCA1, supports a number of fundamental cellular processes. Its absence during embryogenesis is lethal. Loss of function in proliferating…

Ubiquitin Signaling and Bacterial Effector Proteins

Lead Institution
University of Washington
Principal Investigator
Peter Brzovic
Project type
Large-Scale EMSL Research
In plants and animals post-translational modification of proteins by ubiquitin (Ub) is a regulatory process that impacts nearly every aspect of eukaryotic cell biology. Diverse pathways including,…

Structure and Dynamics of aB57.

Lead Institution
University of Washington
Principal Investigator
Ponni Rajagopal
Project type
Capability Research
alphaB-crystallin (aB) is the basic B-subunit of alpha-crystallin, a lenticular protein that is essential for maintaining eye-lens transparency. aB is found associated with a variety of neuro…

NMR Structural Investigations of BRCA1

Lead Institution
University of Washington
Principal Investigator
Rachel Klevit
Project type
Capability Research
Recent identification of the breast and ovarian cancer susceptibility gene, BRCA1, promises to generate a wealth of information concerning breast and ovarian cancer cell biology.

NMR Structural Investigations of BRCA1

Lead Institution
University of Washington
Principal Investigator
Rachel Klevit
Project type
Capability Research
Recent identification of the breast and ovarian cancer susceptibility gene, BRCA1, promises to generate a wealth of information concerning breast and ovarian cancer cell biology.

NMR Structural Investigations of BRCA1

Lead Institution
University of Washington
Principal Investigator
Rachel Klevit
Project type
Capability Research
This project is aimed at gaining structural insights into the biological function and dysfunction of the breast cancer susceptibility protein known as BRCA1. Though the biological role of BRCA1 is…