NMR Structural Investigations of BRCA1
EMSL Project ID
2447a
Abstract
The breast and ovarian cancer tumor suppressor protein, BRCA1, supports a number of fundamental cellular processes. Its absence during embryogenesis is lethal. Loss of function in proliferating breast or ovarian epithelial cells can result in the development of cancer. A growing body of literature suggests that BRCA1 interacts with at least 25 different macromolecules to function in processes such as the cellular response to DNA damage, homologous recombination, transcriptional regulation, and, more recently, ubiquitination. A complete picture of the celluar role of BRCA1 requires a detailed understanding of both the function and the structure of the protein and its interacting partners.
Project Details
Project type
Capability Research
Start Date
2003-04-01
End Date
2004-04-06
Status
Closed
Released Data Link
Team
Principal Investigator
Team Members
Related Publications
Brzovic PS, JR Keeffe, H Nishikawa, K Miyamoto, D Fox, M Fukuda, T Ohta, and RE Klevit. 2003. "Binding and Recognition in the Assembly of an Active BRCA1/BARD1 Ubiquitin-Ligase Complex ." Proceedings of the National Academy of Sciences of the United States of America 100(10):5646-5651.