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NMR Structural Investigations of BRCA1


EMSL Project ID
2447b

Abstract

The breast and ovarian cancer tumor suppressor protein, BRCA1, supports a number of fundamental cellular processes. Its absence during embryogenesis is lethal. Loss of function in proliferating breast or ovarian epithelial cells can result in the development of cancer. A growing body of literature suggests that BRCA1 interacts with at least 25 different macromolecules to function in processes such as the cellular response to DNA damage, homologous recombination, transcriptional regulation, and, more recently, ubiquitination. A complete picture of the celluar role of BRCA1 requires a detailed understanding of both the function and the structure of the protein and its interacting partners.

Project Details

Project type
Capability Research
Start Date
2004-10-01
End Date
2005-10-05
Status
Closed

Team

Principal Investigator

Rachel Klevit
Institution
University of Washington

Team Members

Margaret Daley
Institution
University of Washington

Peter Brzovic
Institution
University of Washington