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Solid-State 67Zn NMR of Synthetic Metalloprotein Models


EMSL Project ID
2452a

Abstract

It is the invention of this proposal to describe studies that will be undertaken in order to aid our understanding of the structures and mechanisms of zinc enzymes. Such knowledge will be obtained by preparing and investigating synthetic analogues that are intended to mimic both the structure and function of a zinc enzyme. These analogues will be compared and contrasted with the native protein via spectroscopic and structural methods, in particular through a combination of X-ray, NMR, EZAFS/XANES spectroscopy. Specifically, the collaborative team intends to address the following aims:

Project Details

Project type
Capability Research
Start Date
2003-10-01
End Date
2004-02-13
Status
Closed

Team

Principal Investigator

Gerard Parkin
Institution
Columbia University