Gerard Parkin

Correlation of Structure and Function of Zinc Metalloproteins Via Solid-state NMR Methods

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Andrew Lipton

Project type

Capability Research

As early as 1869 it was known that zinc is an essential element for eukaryotes, it is the second most abundant trace element in humans after iron. About half of all proteins contain metal cations,…

Correlation of Structure and Function of Zinc Metalloproteins Via Solid-state NMR Methods

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Andrew Lipton

Project type

Capability Research

This project will utilize ab initio molecular orbital theory to aid in the interpretation of the measured field gradients and shielding tensors. These calculations utilize NWCHEM (developed in the…

Correlation of Structure and Function of Zinc Metalloproteins Via a Combined NMR/Molecular Theory Approach

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Andrew Lipton

Project type

Large-Scale EMSL Research

One of the most significant challenges in the metallobiochemistry of Zn2+ is the a priori determination of how the metal center will facilitate a particular chemical reaction. Two examples…

Solid-State 67Zn NMR of Synthetic Metalloprotein Models

Lead Institution

Columbia University

Principal Investigator

Gerard Parkin

Project type

Capability Research

It is the intention of this proposal to describe studies that will be undertaken in order to aid our understanding of the structures and mechanisms of zinc enzymes. Such knowledge will be obtained…

Solid-State 67Zn NMR of Synthetic Metalloprotein Models

Lead Institution

Columbia University

Principal Investigator

Gerard Parkin

Project type

Capability Research

It is the invention of this proposal to describe studies that will be undertaken in order to aid our understanding of the structures and mechanisms of zinc enzymes. Such knowledge will be obtained…

Solid-State 67Zn NMR of Synthetic Metalloprotein Models

Lead Institution

Columbia University

Principal Investigator

Gerard Parkin

Project type

Capability Research

It is the invention of this proposal to describe studies that will be undertaken in order to aid our understanding of the structures and mechanisms of zinc enzymes. Such knowledge will be obtained…

Solid-State 67Zn NMR of Synthetic Metalloprotein Models

Lead Institution

Columbia University

Principal Investigator

Gerard Parkin

Project type

Capability Research

It is the invention of this proposal to describe studies that will be undertaken in order to aid our understanding of the structures and mechanisms of zinc enzymes. Such knowledge will be obtained…

EMSL Science Overview

Gerard Parkin

Projects

Correlation of Structure and Function of Zinc Metalloproteins Via Solid-state NMR Methods

Correlation of Structure and Function of Zinc Metalloproteins Via Solid-state NMR Methods

Correlation of Structure and Function of Zinc Metalloproteins Via a Combined NMR/Molecular Theory Approach

Solid-State 67Zn NMR of Synthetic Metalloprotein Models

Solid-State 67Zn NMR of Synthetic Metalloprotein Models

Solid-State 67Zn NMR of Synthetic Metalloprotein Models

Solid-State 67Zn NMR of Synthetic Metalloprotein Models