electron induced low-dose hypersensetivity
EMSL Project ID
3480
Abstract
Following very low acute radiation exposures, an increase in radiosensitivity has been detected at doses below 1 Gy in a number of cell lines in vitro. This phenomenon is termed ?low-dose hyper-radiosensitivity? or HRS. Cells showing HRS exhibit decreased cell survival, compared with the prediction extrapolated from the response to higher doses (1?5 Gy). We intend to study human glioblastoma cells (T98G). Our group has observed these cells to have a robust HRS response. Using broad-beam electron exposures, we will look for the presence of a HRS response as a function of initial electron kinetic energy.
Project Details
Project type
Exploratory Research
Start Date
2003-05-29
End Date
2005-06-17
Status
Closed
Released Data Link
Team
Principal Investigator
Team Members