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Soft-landing of Peptide Ions on Surfaces

EMSL Project ID
3584
Award DOI
https://dx.doi.org/10.46936/cpcy.proj.2003.3584/60004325

Abstract

 Interaction of ions with surfaces is an area of active fundamental research in surface science relevant to a broad range of other scientific disciplines such as materials science, mass spectrometry, imaging and spectroscopy. Low-energy (1-100 eV) hyperthermal ion beams have been used for surface modification. A unique process that occurs during low-energy collisions of polyatomic ions of some organic surfaces is soft landing (SL). SL is defined as the intact capture in the condensed phase (surfaces of solids or liquids) of mass-selected polyatomic ions. SL of mass-selected ions on surfaces provides a means for highly specific deposition of peptides in surfaces using only a small fraction of material utilized in standard synthetic approaches.
Recently we have developed a novel experimental approach to fundamental studies of factors affecting SL of peptide ions on surfaces. Experiments utilized a specially designed Fourier transform ion cyclotron resonance mass spectrometer (FT-ICR MS) configured for studying interactions of large ions with surfaces. We presented evidence that peptide ions retain at least one proton after SL on FSAM or HSAM surfaces. We will use this research platform to study fundamental aspects of SL.

Project Details

Start Date
2003-05-18
End Date
2006-05-21
Status
Closed
Released Data Link
https://search.emsl.pnnl.gov/?project_id_search=3584

Team

Principal Investigator

Robert Cooks
Institution
Purdue University

Team Members

Jason Green
Institution
Purdue University

Omar Hadjar
Institution
O.I. Analytical

Jormarie Alvarez
Institution
Purdue University

Jean Futrell
Institution
Pacific Northwest National Laboratory

Julia Laskin
Institution
Purdue University

Related Publications

Alvarez J, JH Futrell, and J Laskin. 2006. "Soft-Landing of Peptides onto Self-Assembled Monolayer Surfaces." Journal of Physical Chemistry A 110(4):1678-1687.
Alvarez J, RG Cooks, SE Barlow, DJ Gaspar, JH Futrell, and J Laskin. 2005. "Preparation and in situ Characterization of Surfaces Using Soft-Landing in a Fourier Transform Ion Cyclotron Resonance Mass Spectrometer." Analytical Chemistry 77(11):3452-3460.
Gologan B, JR Green, J Alvarez, J Laskin, and RG Cooks. 2005. "Ion/Surface Reactions and Ion Soft-Landing." Physical Chemistry Chemical Physics. PCCP 7:1490-1500.
Laskin J, P Wang, O Hadjar, JH Futrell, J Alvarez, and RG Cooks. 2007. "Charge Retention by Peptide Ions Soft-Landed onto Self-Assembled Monolayer Surfaces." International Journal of Mass Spectrometry 265(1):237-243.