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Nanoparticle / PDMS-based Microfluidic Device for Environmental Monitoring


EMSL Project ID
39985

Abstract

This proposal is to develop nanoparticle-based microfluidic chips for multiplexed detection of environmental biomarkers. We will choose the poly(dimethylsiloxane) (PDMS) to fabricate the microfluidic device because PDMS has been proven to be a cost-effective material and easy to process for microfluidics. These devices will have multiple channels with multiple reaction zones which will be integrated with an electrode array on a substrate. A portable electrochemical reader will be used for signal readout. We will develop microfluidics-based biosensor devices for rapid, real-time, and cost-effective diagnosis of various environmental biomarkers.

Project Details

Project type
Exploratory Research
Start Date
2010-09-01
End Date
2011-09-04
Status
Closed

Team

Principal Investigator

Jun Wang
Institution
Pacific Northwest National Laboratory

Team Members

Zhifeng Fu
Institution
Southwest University

Donglai Lu
Institution
Pacific Northwest National Laboratory

Zhaohui Li
Institution
Pacific Northwest National Laboratory

Ying Wang
Institution
Tsinghua University

Guocheng Shao
Institution
Louisiana State University

Dan Du
Institution
Pacific Northwest National Laboratory

Honggang Liao
Institution
Xiamen University

Chiann-tso Lin
Institution
Pacific Northwest National Laboratory

Ryan Kelly
Institution
Brigham Young University

Yuehe Lin
Institution
Washington State University

Hong Wu
Institution
Pacific Northwest National Laboratory

Related Publications

Du D, L Wang, Y Shao, J Wang, MH Engelhard, and Y Lin. 2011. "Functionalized Graphene Oxide as a Nanocarrier in a Multienzyme Labeling Amplification Strategy for Ultrasensitive Electrochemical Immunoassay of Phosphorylated p53 (S392)." Analytical Chemistry 83(3):746-752. doi:10.1021/ac101715s
Liu B, D Du, X Hua, XY Yu, and Y Lin. 2014. "Papers Based Electrochemical Biosensors: From Test Strips to Paper-Based Microfluidics." Electroanalysis 26(6):1214-1223. doi:10.1002/elan.201400036
Pinwattana K, J Wang, CT Lin, H Wu, D Du, Y Lin, and O Chailapakul. 2010. "CdSe/ZnS quantum dots based electrochemical immunoassay for the detection of phosphorylated bovine serum albumin." Biosensors and Bioelectronics 26(3):1109-1113 . doi:10.1016/j.bios.2010.08.021
Shao G, J Wang, Z Li, LV Saraf, W Wang, and Y Lin. 2011. "Poly(dimethylsiloxane) microchip-based immunoassay with multiple reaction zones: Toward on-chip multiplex detection platform." Sensors and Actuators. B, Chemical 159(1):44-50. doi:10.1016/j.snb.2011.06.032
Wang Y, S Zhang, D Du, Y Shao, Z Li, J Wang, MH Engelhard, J Li, and Y Lin. 2011. "Self assembly of acetylcholinesterase on a gold nanoparticles–graphene nanosheet hybrid for organophosphate pesticide detection using polyelectrolyte as a linker ." Journal of Materials Chemistry 21(14):5319-5325. doi:10.1039/C0JM03441J
Wang Y, Z Li, M Liu, D Hu, Y Lin, and J Li. 2017. "Multiple-Targeted Graphene-based Nanocarrier for Intracellular Imaging of mRNAs." Analytica Chimica Acta 983:1-8. doi:10.1016/j.aca.2017.07.017