Nanoparticle / PDMS-based Microfluidic Device for Environmental Monitoring
EMSL Project ID
39985
Abstract
This proposal is to develop nanoparticle-based microfluidic chips for multiplexed detection of environmental biomarkers. We will choose the poly(dimethylsiloxane) (PDMS) to fabricate the microfluidic device because PDMS has been proven to be a cost-effective material and easy to process for microfluidics. These devices will have multiple channels with multiple reaction zones which will be integrated with an electrode array on a substrate. A portable electrochemical reader will be used for signal readout. We will develop microfluidics-based biosensor devices for rapid, real-time, and cost-effective diagnosis of various environmental biomarkers.
Project Details
Project type
Exploratory Research
Start Date
2010-09-01
End Date
2011-09-04
Status
Closed
Released Data Link
Team
Principal Investigator
Team Members
Related Publications
Du D, L Wang, Y Shao, J Wang, MH Engelhard, and Y Lin. 2011. "Functionalized Graphene Oxide as a Nanocarrier in a Multienzyme Labeling Amplification Strategy for Ultrasensitive Electrochemical Immunoassay of Phosphorylated p53 (S392)." Analytical Chemistry 83(3):746-752. doi:10.1021/ac101715s
Liu B, D Du, X Hua, XY Yu, and Y Lin. 2014. "Papers Based Electrochemical Biosensors: From Test Strips to Paper-Based Microfluidics." Electroanalysis 26(6):1214-1223. doi:10.1002/elan.201400036
Pinwattana K, J Wang, CT Lin, H Wu, D Du, Y Lin, and O Chailapakul. 2010. "CdSe/ZnS quantum dots based electrochemical immunoassay for the detection of phosphorylated bovine serum albumin." Biosensors and Bioelectronics 26(3):1109-1113 . doi:10.1016/j.bios.2010.08.021
Shao G, J Wang, Z Li, LV Saraf, W Wang, and Y Lin. 2011. "Poly(dimethylsiloxane) microchip-based immunoassay with multiple reaction zones: Toward on-chip multiplex detection platform." Sensors and Actuators. B, Chemical 159(1):44-50. doi:10.1016/j.snb.2011.06.032
Wang Y, S Zhang, D Du, Y Shao, Z Li, J Wang, MH Engelhard, J Li, and Y Lin. 2011. "Self assembly of acetylcholinesterase on a gold nanoparticles–graphene nanosheet hybrid for organophosphate pesticide detection using polyelectrolyte as a linker ." Journal of Materials Chemistry 21(14):5319-5325. doi:10.1039/C0JM03441J
Wang Y, Z Li, M Liu, D Hu, Y Lin, and J Li. 2017. "Multiple-Targeted Graphene-based Nanocarrier for Intracellular Imaging of mRNAs." Analytica Chimica Acta 983:1-8. doi:10.1016/j.aca.2017.07.017