Proteomics Identification Characterization of Biological Agents and Toxins
EMSL Project ID
50693
Abstract
Biological toxins are of human health and biosecurity concern. Identification of such toxins often relies on enzyme-linked immunosorbent assay (ELISA) methods, but orthogonal approaches are desired. The objective of this project is to develop mass spectrometry-based assays to identify and characterize protein and peptide toxins. The potential impact of this research is wide-reaching, including application in the public health, law enforcement and national security fields. Utilization of EMSL resources, specifically the Q-Exactive HF instrument, will be essential for generation of high quality data for use in downstream data analysis applications and to align with end-user instrumentation. Since toxins will either be analyzed in inactive forms or at low levels, no significant toxicity risks are anticipated.
Project Details
Start Date
2019-04-01
End Date
2021-09-30
Status
Closed
Released Data Link
Team
Principal Investigator