Eric Merkley | Environmental Molecular Sciences Laboratory

Proteomics Identification Characterization of Biological Agents and Toxins

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Eric Merkley

Biological toxins are of human health and biosecurity concern. Identification of such toxins often relies on enzyme-linked immunosorbent assay (ELISA) methods, but orthogonal approaches are desired…

Integrated multi-modal approach for structure and function determination of lignin-forming protein complexes isolated from plants

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

John Cort

We propose to apply an integrated multi-modal structural biology approach to investigate a biosynthetic protein complex in plants that is hypothesized to organize and guide lignin biosynthesis via…

High-Throughput Proteomics: Applications and Development (PNNL Scope #40601 and #43488)

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Gordon Anderson

This project involves the application and development of high-throughput proteomics and quantitative measurement capabilities within biological systems. More so, application measurements will be…

Collaborative research projects in the PNNL NIH NCRR P41 Biomedical Technology Research Center 'Proteomics research resource for integrative biology'

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

David Camp

Collaborative research projects in the PNNL NIH NCRR P41 Biomedical Technology Research Center 'Proteomics research resource for integrative biology'

Characterization of Effector and Host Proteins Involved in Host-Pathogen Interactions

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Joshua Adkins

Project type

Exploratory Research

The multiple mechanisms by which pathogenic enterobacteria of the genus Salmonella infect their host indicate a complex host-pathogen relationship. The pathogen secretes dozens of proteins, termed &…

Pan-Omics Technology Development, Implementation, and Application to GSP Systems Biology Research

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Joshua Adkins

The BER Genome Science Program aims to understand complex biological and environmental systems across spatial and temporal scales to develop predictive knowledge relevant to DOE mission challenges…

Characterization of Effector and Host Proteins Involved in Host-Pathogen Interactions

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Joshua Adkins

The multiple mechanisms by which pathogenic enterobacteria of the genus Salmonella infect their host indicate a complex host-pathogen relationship. The pathogen secretes dozens of proteins, termed &…

Discovery of Host Proteins Involved in Host-Pathogen Interactions

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Joshua Adkins

The multiple mechanisms by which pathogenic enterobacteria of the genus Salmonella infect their host indicate a complex host-pathogen relationship. The pathogen secretes dozens of proteins, termed &…

Pan-Omics Technology Development, Implementation, and Application to GSP Systems Biology Research

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Joshua Adkins

The BER Genome Science Program aims to understand complex biological and environmental systems across spatial and temporal scales to develop predictive knowledge relevant to DOE mission challenges…

Discovery of Host Proteins Involved in Host-Pathogen Interactions

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Joshua Adkins

The multiple mechanisms by which pathogenic enterobacteria of the genus Salmonella infect their host indicate a complex host-pathogen relationship. The pathogen secretes dozens of proteins, termed &…

Pan-Omics Technology Development, Implementation, and Application to GSP Systems Biology Research

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Joshua Adkins

The BER Genome Science Program aims to understand complex biological and environmental systems across spatial and temporal scales to develop predictive knowledge relevant to DOE mission challenges…

Methods for Biological Toxin Identification

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Karen Wahl

Biological toxins are of human health and biosecurity concern. Identification of such toxins often relies on enzyme-linked immunosorbent assay (ELISA) methods, but orthogonal approaches are desired…

Using High-Resolution Mass Spectrometry, NMR and Computation to Elucidate Biomolecular Structural Features that Enable Efficient Oxygen Reduction Reaction Catalysis in Fuel Cells

Lead Institution

University of Texas at Austin

Principal Investigator

Yi Lu

Project type

Large-Scale EMSL Research

This proposal addresses a major under-explored area of research in our understanding of foundational principles for predictive biology central to energy production, i.e., the role of post…

Yarrowia lipolytica for biotechnology and synthetic biology

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Erin Bredeweg

The team at PNNL is using a combination of flow cytometry, microscopy and lipidomics/metabolomics to establish baseline cell biological and metabolite data on DNA agility in eukaryotic organisms, and…

Projects