Structure of the TRAMP RNA surveillance complex
EMSL Project ID
51036
Abstract
This proposal seeks access to the PNCC cryo-EM facility in order to obtain structural information for the TRAMP (Trf4-Air2-Mtr4 polyadenylation) complex. The goal is to better understand assembly of the complex and its interaction with RNA substrates. TRAMP is an essential eukaryotic protein complex that plays a central role in RNA quality control and degradation. Cryo-EM structures are expected to provide significant insight into assembly of the complex and mechanisms employed to identify and process RNA.
Project Details
Start Date
2019-10-15
End Date
2021-03-17
Status
Closed
Released Data Link
Team
Principal Investigator
Team Members