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Structure of the TRAMP RNA surveillance complex


EMSL Project ID
51036

Abstract

This proposal seeks access to the PNCC cryo-EM facility in order to obtain structural information for the TRAMP (Trf4-Air2-Mtr4 polyadenylation) complex. The goal is to better understand assembly of the complex and its interaction with RNA substrates. TRAMP is an essential eukaryotic protein complex that plays a central role in RNA quality control and degradation. Cryo-EM structures are expected to provide significant insight into assembly of the complex and mechanisms employed to identify and process RNA.

Project Details

Start Date
2019-10-15
End Date
2021-03-17
Status
Closed

Team

Principal Investigator

Sean Johnson
Institution
Utah State University

Team Members

Joshua Denson
Institution
Utah State University

Janette Myers
Institution
Oregon Health & Science University

Irina El Khoury
Institution
Environmental Molecular Sciences Laboratory