Structural biology of synaptic and extrasynaptic GABAA receptors
EMSL Project ID
51259
Abstract
GABAA receptors are pentameric ligand-gated ion channels and mediate the majority of fast inhibitory signaling in the brain. Here we propose to characterize the structural pharmacology of receptors that are found at synapses as well as receptor subtypes found outside of synapses to understand principles of drug selectivity and receptor architecture. We aim to examine structural complexes with benzodiazepines, anesthetics and a physiological ethanol antagonist. The results will reveal the architectures of difference conformational states of the receptors in principles of ligand recognition underpinning the particularly rich pharmacology of this ligand-gated ion channel family.
Project Details
Start Date
2020-01-15
End Date
2021-03-17
Status
Closed
Released Data Link
Team
Principal Investigator
Team Members
Related Publications
Shared structural mechanisms of general anaesthetics and benzodiazepines.
Kim JJ, Gharpure A, Teng J, Zhuang Y, Howard RJ, Zhu S, Noviello CM, Walsh RM Jr, Lindahl E, Hibbs RE.
Nature. 2020 Sep 2. doi: 10.1038/s41586-020-2654-5. Online ahead of print.
PMID: 32879488