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Cryo-EM studies of drug transporters


EMSL Project ID
51743

Abstract

The SLC superfamily of membrane transporters play critical roles in many aspects of human physiology and pharmacology. Several SLC transporters play roles in drug transport. Of note, nucleoside transporters are important contributors to nucleoside physiology, making them desirable targets to modulate nucleoside-mediated cell signaling. Further, nucleoside transporters control the cellular uptake of nucleoside-analog anticancer drugs and serve as predictive markers of patient response to such chemotherapies. To gain deeper understanding of the functional mechanisms exhibited by these membrane transporters, we propose to pursue cryo-EM studies to elucidate structures of these transporters in various conformational states as well as in complex with various drugs. Our studies will provide the platform to develop therapeutics against cancer or ischemia-reperfusion injury.

Project Details

Start Date
2020-11-15
End Date
2021-03-17
Status
Closed

Team

Principal Investigator

Seok-Yong Lee
Institution
Duke University

Team Members

Justin Fedor
Institution
Duke University

Nicholas Wright
Institution
Duke University

Irina El Khoury
Institution
Environmental Molecular Sciences Laboratory