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Seok-Yong Lee

Institution
Duke University
ORCID
ORCID logo 0000-0002-0662-9921

Projects

Collaborative Access Team: Pacific Northwest Cryo-EM Center (PNCC)

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
James Evans
PNNL will create and operate the Pacific Northwest Center for Cryo-EM (PNCC), a state-of-the-art national center for cryo-electron microscopy (Cryo-EM) that will rapidly and efficiently collect and…

Cryo-EM studies of TRP channels

Lead Institution
Duke University
Principal Investigator
Seok-Yong Lee
Transient receptor potential (TRP) channels are a superfamily of calcium-permeable ion channels that are involved in diverse physiological processes. A subset of TRP channels that are known as the…

Cryo-EM studies of drug transporters

Lead Institution
Duke University
Principal Investigator
Seok-Yong Lee
The SLC superfamily of membrane transporters play critical roles in many aspects of human physiology and pharmacology. Several SLC transporters play roles in drug transport. Of note, nucleoside…

Single-particle cryo-EM structural studies of TRPM channels

Lead Institution
Duke University
Principal Investigator
Seok-Yong Lee
The transient receptor potential melastatin (TRPM) family of ion channels are the largest and most diverse group within the TRP channel superfamily. They are broadly distributed across various tissue…

Single-particle Cryo-EM studies of calcium-permeable Ion channels

Lead Institution
Duke University
Principal Investigator
Seok-Yong Lee
Calcium-permeable ion channels play crucial roles in cellular calcium signaling and thus many key physiological processes. Transient receptor potential (TRP) ion channels play major roles in sensory…