Single-particle cryo-EM structural studies of TRPM channels
EMSL Project ID
51815
Abstract
The transient receptor potential melastatin (TRPM) family of ion channels are the largest and most diverse group within the TRP channel superfamily. They are broadly distributed across various tissue and cell types and is involved in regulating diverse physiological processes. Members that serve as key players somatosensation have emerged as promising targets for developing novel therapeutics for treatment of pain and inflammation. To accomplish successful analgesic drug designs, besides functional studies, structural analyses are indispensable for understanding the underlying mechanisms of activation and regulation of these channels. Here we propose to investigate the molecular basis of nociceptive TRPM channels employing protein biochemistry and single-particle cryo-electron microscope as our primary strategies. Our studies will prompt the sensory biology field to progress towards a clearer mechanistic understanding of TRP channel functions.
Project Details
Start Date
2021-02-15
End Date
2021-03-17
Status
Closed
Released Data Link
Team
Principal Investigator
Team Members