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Single-particle Cryo-EM studies of calcium-permeable Ion channels


EMSL Project ID
51816

Abstract

Calcium-permeable ion channels play crucial roles in cellular calcium signaling and thus many key physiological processes. Transient receptor potential (TRP) ion channels play major roles in sensory transduction. Recent studies have revealed that several classes of calcium permeable ion channels that do not belong to the TRP channel family, are also either involved in sensory transduction or their functions are significantly modulated by sensory signals. Their diverse ion permeation and gating properties tune the cellular calcium uptake in sensory systems. We aim to uncover to the mechanisms of calcium uptake by these calcium permeable ion channels. We propose to pursue cryo-EM studies to elucidate conformational landscapes of these ion channels using various ligands and drugs. Comprehensive structural and mechanistic studies of these ion channels would facilitate the development of drugs addressing neurological or immune disorders

Project Details

Start Date
2021-02-15
End Date
2021-03-17
Status
Closed

Team

Principal Investigator

Seok-Yong Lee
Institution
Duke University

Team Members

Zhenning Ren
Institution
Duke University

Dohoon Kwon
Institution
Duke University