Single-particle Cryo-EM studies of calcium-permeable Ion channels
EMSL Project ID
51816
Abstract
Calcium-permeable ion channels play crucial roles in cellular calcium signaling and thus many key physiological processes. Transient receptor potential (TRP) ion channels play major roles in sensory transduction. Recent studies have revealed that several classes of calcium permeable ion channels that do not belong to the TRP channel family, are also either involved in sensory transduction or their functions are significantly modulated by sensory signals. Their diverse ion permeation and gating properties tune the cellular calcium uptake in sensory systems. We aim to uncover to the mechanisms of calcium uptake by these calcium permeable ion channels. We propose to pursue cryo-EM studies to elucidate conformational landscapes of these ion channels using various ligands and drugs. Comprehensive structural and mechanistic studies of these ion channels would facilitate the development of drugs addressing neurological or immune disorders
Project Details
Start Date
2021-02-15
End Date
2021-03-17
Status
Closed
Released Data Link
Team
Principal Investigator
Team Members