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Structure and function of connexin-46/50 gap junction channels


EMSL Project ID
51785

Abstract

The gap junctions are a class of membrane channel proteins that form direct pathways for cell-to-cell communication. Dynamic mechanisms of channel gating are required to control these communication pathways, while their mis-regulation is associated with a range of pathophysiological conditions, including blindness, deafness, cardiac arrhythmia, stroke and cancers. Our research group is using methods in high-resolution single particle cryo-microscopy (CryoEM) to understand the detailed mechanisms of gap junction regulation and how aberrant regulation of inter-cellular communication manifests in disease.

Project Details

Start Date
2020-12-15
End Date
2021-03-17
Status
Closed

Team

Principal Investigator

Steve Reichow
Institution
Portland State University

Team Members

Joshua Jarodsky
Institution
Portland State University

Susan O'neill
Institution
Portland State University

Jonathan Flores
Institution
Oregon Health & Science University

Irina El Khoury
Institution
Environmental Molecular Sciences Laboratory