Structure and function of connexin-46/50 gap junction channels
EMSL Project ID
51785
Abstract
The gap junctions are a class of membrane channel proteins that form direct pathways for cell-to-cell communication. Dynamic mechanisms of channel gating are required to control these communication pathways, while their mis-regulation is associated with a range of pathophysiological conditions, including blindness, deafness, cardiac arrhythmia, stroke and cancers. Our research group is using methods in high-resolution single particle cryo-microscopy (CryoEM) to understand the detailed mechanisms of gap junction regulation and how aberrant regulation of inter-cellular communication manifests in disease.
Project Details
Start Date
2020-12-15
End Date
2021-03-17
Status
Closed
Released Data Link
Team
Principal Investigator
Team Members