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Computational study of protein-protein interaction dynamics


EMSL Project ID
5690

Abstract

Protein-protein interactions are extremely important and complex in living
cells. Studying the dynamical processes of protein-protein interactions is
crucial for uncovering the fundamental mechanisms and dynamics governing
cellular functions, such as the cell signaling processes. It would also
help the understanding of the complex biological network involving
protein-protein interactions in bacterial cells. In this project, we plan
to carry out a systematic simulation study on the dynamics of
protein-protein interactions using our new parallel computation facility.
These new capability and fundamental understanding will significantly
enhance our single-molecule spectroscopy studies on protein-protein
interaction dynamics in Genome-To-Life (DOE) and System Biology Initiative
(LDRD; PNNL) projects.

Project Details

Project type
Capability Research
Start Date
2004-01-30
End Date
2006-02-06
Status
Closed

Team

Principal Investigator

Jin Wang
Institution
State University of New York at Stony Brook

Team Members

Qiang Lu
Institution
State University of New York at Stony Brook

H. Peter Lu
Institution
Bowling Green State University